When it comes to building the immune system quickly and effectively, nothing provides more protection than the Exposure Protection Pak.
Every Exposure Protection Pak box contains 30 individual packets, with seven capsules in each—a total of 210 capsules. And each of these 210 capsules is jam-packed with nutrients proven by research to help build a powerful immune system. On this page we we provide a “mini archive” of some of that research. You can use this info to start your own research; however, this is just a sampling of the extensive research on these nutrients: Vitamin A • Vitamin A is a critical immune-building nutrient, and supplementing it could prevent thousands of Tuberculosis deaths each year, according to research published in The Journal of Immunology in March 2014. [Study details.] • A Purdue University study found that critical immune cells protecting the body from infection would be lost without “directions” provided by Vitamin A. The study was published in the journal Immunity in June 2015. [Study details.] • Vitamin A as one of the five vitamins critical in the prevention of Covid deaths, according to findings published in British Medical Journal – Nutrition, Prevention and Health. The research was published in April 2020. [Study details.] Vitamin C • A 2018 meta-analysis of nine randomized studies found extra therapeutic doses of Vitamin C at the onset of colds helped reduce the duration of symptoms. Study published on PubMed Central July 2018. [Study details.] • A review of six controlled trials by researchers at the University of Helsinki found that Vitamin C shortened hospital patients’ time in ICU by an average of 8.6%. The study was published in Nutrients in March 2019. [Study details.] • A meta-analysis of 10 randomized control trials found cold symptoms were shorter for patients supplementing Vitamin C compared to patients who were administered antiviral therapy alone. The study was published in PubMed Central in April 2021. [Study details.] Vitamin D • Clear back in 2010 researchers at the University of Copenhagen established that Vitamin D is crucial to activating our immune defenses. They showed that without sufficient intake of the vitamin, the killer cells of the immune system (known as “T cells”) are not able to react to and fight off serious infections in the body. The research was published in Nature Immunology in March of that year. [Study details.] • Jumping forward to 2017 a worldwide study led by researchers at Queen Mary University of London found that Vitamin D supplements “protect against acute respiratory infections including colds and flu.” The results were based on an analysis of raw data from around 11,000 participants in 25 clinical trials conducted in 14 countries. The study was published in the British Medical Journal in February 2017. [Study details.] • The most critical Vitamin D findings come courtesy of the Covid pandemic. At the onset of the pandemic individual countries almost immediately found a link between Vitamin D deficiency and high mortality rates. In 2020, research led by Northwestern University confirmed the individual findings when they analyzed patient data from 10 different countries. The researchers found that patients from countries with high COVID-19 mortality rates had lower levels of Vitamin D compared to patients in countries that were not as severely affected. The findings were published online at MedRxiv in April 2020. [Study abstract.] Vitamin E Though typically thought of as the crucial vitamin for eye, skin and hair health, in recent years researchers have also studied the immune-supporting characteristics of Vitamin E: • A 2011 study published in Vitamins & Hormones found supplementation with Vitamin E “significantly enhances both cell mediated and humoral immune functions in humans, especially in the elderly and animals.” [Study is archived at Science Direct database here.] • A review published in Nutrients in November 2018 concluded that Vitamin E had been shown to enhance immune responses in animal and human models and to “confer protection” against a number of infectious diseases. [Study details.] Vitamin K • Studies conducted in The Netherlands and New Zealand are just two of the many 2020 studies that found low Vitamin K status in Covid-19 patients was associated with a greater risk of mortality. The risk was related to the Matrix Gla Protein, one of the body’s proteins which is dependent on adequate levels of Vitamin K2 to become active. In general, higher circulating Matrix Gla Protein means healthier arteries and immune function. [PubMed Central archive – The Netherlands study] • [PubMed Central archive – New Zealand hypothesis study] • A Tufts University long-term study found adults aged 54-76 with low circulating Vitamin K levels were more likely to die within 13 years compared to those with adequate levels—suggesting Vitamin K provides protective health benefits as people age. The results were published in The American Journal of Clinical Nutrition in June 2020. [Study details.] • In 2021 researchers at University Hospitals Cleveland found that deficiencies in both Vitamin K and Vitamin D were independently associated with worse COVID-19 disease severity. The researchers stated their findings indicated “a potential synergistic interplay between these two vitamins in COVID-19.” The research was published in Oxford Academic’s Open Forum Infectious Diseases in October 2021. [Study details.] B-vitamins • Research conducted at the Linus Pauling Institute at Oregon State University found that vitamin B3 was effective in helping combat the antibiotic-resistant bacterial infections that are becoming increasingly common around the world. The study was published in the Journal of Clinical Investigation in August 2012. [Study details.] • According to research conducted at Swinburne University in Melbourne, Australia, supplementing with a complex of B-vitamins was effective in “reducing oxidative stress and inflammation through increasing oxidative metabolism.” The research was published in Nutrients in October 2018. [Study details.] • A report published by medical researchers at Singapore General Hospital found a combination of nutritional supplements, including B-12, could “reduce the progression of COVID-19 into the severe or fatal stages.” The paper was published June 2020 on the MedRxIv medical platform. [Study details.]
Calcium • For the first time, in 2013, scientists studying the cellular processes underlying the body’s response to healing demonstrated how a “flash” of calcium is the initial trigger in the immune response. The research was conducted at University of Bristol and the findings were published in Current Biology in March 2013. [Study details.] • Research published in 2016 found that “calcium signals play a vital role in keeping the immune system finely balanced, ramping responses up and down at the appropriate time.” The study was conducted by scientists at NYU Langone Medical Center, in collaboration with researchers at at the University of Wurzberg in Germany, and the findings were published in the journal Immunity in May 2016. [Study details.] • Calcium deficiency (Hypocalcaemia) has long been associated with an increased risk of acute respiratory failure and mortality among critically ill patients. A 2020 study conducted on hospital patients in China found this was also true relative to Covid-19 patients. The conclusion of the researchers was: “Hypocalcemia commonly occurred in severe COVID-19 patients and it was associated with poor outcome.” The study was published in the Journal of Infection and Public Health in October 2020. [Study archived in Science Direct database here.] Iron According to the Linus Pauling Institute, iron deficiency is the most common nutritional deficiency worldwide. This is unfortunate since iron is critical for healthy blood and proper immune functioning. The Cleveland Clinic, which lists iron as one of the eight vitamins and minerals needed for a healthy immune system, states: “Iron helps your body carry oxygen to cells and plays a part in many of the immune system processes.” • Almost 20 years ago a Pennsylvania State University study published findings that low iron status can have serious immune consequences as people age. The study reported that iron deficiency impaired levels of immunity from 28% to 50% in test subjects who were over the age of 60. Study results were published in The American Journal of Medicine in August 2004. [Study details.] • A 2015 study found that blood donors who took an iron supplement were able to restore hemoglobin concentration substantially faster than test subjects who did not take an iron supplement. The researchers found that recovery of hemoglobin in participants who received supplements took a median of 76 days; meanwhile, participants not taking the supplements had a median recovery time that was longer than 168 days. The findings were published in the Journal of the American Medical Association in February 2015. [Study details.] • A 2021 Chinese study COVID-19 patients with iron deficiency had an “8.2 times greater possibility of developing severe pneumonia and requiring timely intervention and attention” compared to patients without anemia. The research was conducted by scientists at Huazhong University in Wuhan, and the results were published in Future Virology in July 2021. [Study detail.] Kelp • Thyroid hormones play essential roles in both the innate and adaptive immune responses, and kelp supports thyroid health with its high iodine content. In a 2011 Japanese study kelp improved thyroid function of patients with severe motor and intellectual disabilities and hypothyroidism due to iodine deficiency. When patients were given powdered kelp daily their thyroid function was restored, increasing the concentration of iodine in the urine. In another study, conducted in the U.S., supplementing with kelp increased the levels of the hormone that stimulates the thyroid gland (thyrotropin). [Japanese study in Clinical Pediatric Endocrinology.] [U.S. study in Endocrine Practice.] • Research published in 2015 found fucoidan extracted from kelp had a variety of immune-modulation effects, such as promoting natural killer cells and T cells, and enhancing anti-viral and anti-tumor responses. The researchers, which included scientists from the U.S., China and Japan, concluded that fucoidan “can be potentially useful as a therapeutic agent for infectious diseases.” The study was published in Marine Drugs in March 2015. [Study details.] • A 2017 Chinese study revealed that fucoidan extracted from kelp blocked influenza infection in vitro. The researchers reported that fucoidan was able to “inactivate virus particles before infection and some stages after adsorption.” In addition, fucoidan was able to prolong the survival time of virus-infected mice, and presented an ability to “significantly improve the quality of immune organs, immune cell phagocytosis and humoral immunity.” The study was published in Scientific Reports in January 2017. [Study details.] • A review of existing studies on kelp conducted in India in 2020 concluded that kelp extracts held the potential to open new avenues to designing therapeutic products not only for COVID‐19, but also for the other viral infections: “We conclude that based on the available reports algal metabolites hold promising potential for the development of novel anti‐viral therapeutics,” the researchers wrote in their summary. [All studies cited in the review can be seen at PubMed’s Wiley Public Health Emergency Collection.] Magnesium • A broad-range 2003 study which was reviewing the link between magnesium and immune health concluded: “There is a strong relation between magnesium and the immune system.” The many areas of examination included magnesium’s involvement in inflammation, apoptosis, thymocyte gene expression, asthma, aging processes, and apoptosis in humans. The results were published in the European Journal of Clinical Nutrition in September 2003. [Study details at Nature.com database here.] • The magnesium immune benefit that is most often cited by health experts is its critical function in enabling Vitamin D metabolism in the human body. A 2018 study conducted by researchers from Vanderbilt University, Harvard Medical School and Purdue University found that “optimal magnesium status was related to healthy Vitamin D levels.” The double-blind randomized controlled trial was published in The American Journal of Clinical Nutrition in December 2018. [Study details.] • In a review entitled “The relevance of magnesium homeostasis in COVID-19,” researchers studying the link between COVID-19 and magnesium deficiency concluded: “Existing data seem to corroborate an association between deranged magnesium homeostasis and COVID-19.” The researchers further noted that they hoped to encourage “a deeper appreciation of magnesium” in view of its role in chronic non-communicable diseases and infectious diseases. The findings were published in the European Journal of Nutrition in October 2021. [The complete review, with links to all the studies cited, can be found in PubMed database here.] Zinc • A Harvard University meta-analysis reviewing the effectiveness of vitamins and minerals in treating acute respiratory tract infections found that zinc supplementation “substantially shortened the duration of symptoms.” The researchers reported their study included 80 random controlled trials and that the research was a “synthesis of global evidence from randomized controlled trials.” The findings were published in the British Medical Journal in December 2020. [Study details at BMJ Global Health.] Selenium • According to 2004 research published in The American Journal of Clinical Nutrition, selenium supplements boosted the immune response in test subjects. The improved immune response was measured by increased production of interferon gamma and other cytokines, an earlier peak T cell proliferation, and an increase in T helper cells. Test subjects who received selenium supplements also showed more rapid clearance of the poliovirus. The study was conducted by researchers from the University of Liverpool and the Rowett Research Institute in the UK and was published in July 2004. [Study details.] • A 2019 study showed that selenium supplementation reduced oxidative stress by increasing total antioxidant capacity and glutathione peroxidase levels. Supplementation also decreased the level of serum malonaldehyde. All of these processes are crucial factors for reduction of oxidative stress—and, in turn, a reduction in inflammation. The study was published in Hormones in December 2019, and was updated in July 2020. [Study is archived in the Springer Link database here.] Copper • The disease fighting properties of copper have been recognized for literally thousands of years, with uses dating back to ancient Egypt. With this in mind, much of the research on copper has f